Tissue stem cells in aging and regenerative medicine
We study how self-renewal is regulated in tissue stem cells.
NEWS
MESSAGE
Welcome to Ito Lab
Our lab has broad interests in the regulation of cell fates in stem cells and cancer in animals.
We study how stem cell fates are determined and regulated in healthy tissues and organs. We are also working hard to figure out how the regulatory mechanisms for cell fate decision can go awry and drive cancer development and progression. Our recent obsessions include metabolism and cell fates in cancers such as myeloid leukemia. Through our work, we aim to understand the biochemistry behind cell fate regulation. We hope our findings can contribute to developing safe and effective therapeutic strategies for tissue regeneration, frailty and cancer in human. In the lab, we value communication, diversity and inclusion. Explore our website to learn more about us!
- Institute for Frontier Life and Medical Sciences,
Kyoto University 
RESEARCH
Cancer, stem cells and cancer stem cells
Self-renewal can be a target of malignant transformation leading to cancer development.
Metabolic regulation of cell fates in cancer
We begin to understand how cellular metabolism affects cancer development and progression.
PUBLICATIONS
- Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia.
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison A, Ito T.
Nature 545:500-504 (2017). - Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.
Zimdahl B#, Ito T#, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T.
Nat Genet 46:245-52 (2014). - Regulation of myeloid leukaemia by the cell fate determinant Musashi.
Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T.
Nature 466:765-8 (2010)