PUBLICATIONS

2024.03.27: Targeted Genetic and Small Molecule Disruption of N-Ras Caax Cleavage Alters its Localization and Oncogenic Potential.
Hildebrandt ER, Hussain SA, Sieburg MA, Ravishankar R, Nadeem A, Gore S, Ito T, Hougland JL, Dore TM, Schmidt WK.
Bioorg Chem (2024).

2024.02.19: The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation. https://pubmed.ncbi.nlm.nih.gov/38373797/
Wang R, Kato F, Yasui-Watson R, Beedle AM, Call JA, Tsunoda Y, Noda T, Tsuchiya T, Kashima M, Hattori A, Ito T.
Life Sci Alliance (2024).

2023.07.25: Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia. https://pubmed.ncbi.nlm.nih.gov/37491463/
Hattori A, Takamatsu-Ichihara E, Yamamoto Y, Fujita S, Yamagata K, Katsumoto T, Machida Y, Shinohara H, Murakami R, Kitabayashi I.
Leukemia 37:1812-1829 (2023).

2022.11.09: Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia. https://pubmed.ncbi.nlm.nih.gov/36352193/
Jimbo K, Hattori A, Koide S, Ito T, Sasaki K, Iwai K, Nannya Y, Iwama A, Tojo A, Konuma T.
Leukemia 37:122-133 (2023).

2022.04.13: Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation.
Jimbo K, Nakajima-Takagi Y, Ito T, Koide S, Nannya Y, Iwama A, Tojo A, Konuma T.
Leukemia (2022).

2022.04.13: Determination of intracellular 2-hydroxyglutarate enantiomers using two-dimensional liquid chromatography.
Ohtawa T, Hattori A, Isokawa M, Harada M, Funatsu T, Ito T, Tsunoda M.
J Chrom Open 1:100005 (2021).

2021.08.12: The CD44/COL17A1 pathway plays a vital role in the formation of multilayered, transformed epithelia.
Kozawa K, Sekai M, Ohba K, Ito S, Sakoh H, Maruyama T,Kakeno M, Shirai T, Kamasaki T, Kohashi K, Tanaka S, Ishikawa S, Sato N, Asano S, Suzuki H, Tanimura N, Mukai Y,Gotoh N, Tanino M, Tanaka S, Natsuga K, Soga T, Nakamura T, Yabuta Y, Saitou M, Ito T, Matsuura K, Tsunoda M, Kikumori T, Iida T, Mizutani Y, Miyai Y, Enomoto A, Fujita Y.
Curr Biol 31:3086-97 (2021).

2020.11.26: A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.
Spinler K, Bajaj J, Ito T, Zimdahl B, Hamilton M, Ahmadi A, Koechlein CS, Lytle N, Kwon HY, Anower-E-Khuda F, Sun H, Blevins A, Weeks J, Kritzik M, Karlseder J, Ginsberg MH, Park PW, Esko J, Reya T.
Nat Commun 11:5998 (2020).

2020.05.21: Analysis of intracellular α-keto acids by HPLC with fluorescence detection
Fujiwara T, Hattori A, Ito T, Funatsu T, Tsunoda M
Analytical Methods 20. doi:10.1039/D0AY00556H (2020).

2019.04.30: Continuous in vivo metabolomics by NMR.
Judge M, Wu Y, Tayyari F, Hattori A, Glushka J, Ito T, Arnold J, Edison A.
Front Mol Biosci 6:26. doi:10.3389/fmolb.2019.00026 (2019).

2017.10.20: Analysis of branched-chain keto acids in cell extracts by HPLC-fluorescence detection.
Hattori A, Ito T, Tsunoda M.
Chromatography 38:129-33 (2017).

2017.05.17: Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia.
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison A, Ito T.
Nature 545:500-504 (2017).
Research highlighted in Cancer Discovery and F1000Prime

2017.03.01: RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia.
Hattori A, McSkimming D, Kannan N, Ito T.
Leuk Res 54:47-54 (2017).

2016.10.06: Regulation of stem cell self-renewal and oncogenesis by RNA-binding proteins.
Hattori A, Buac K, Ito T.
Adv Exp Med Biol 907:153-88 (2016).

2016.07.18: High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.
Koechlein CS, Harris JR, Lee TK, Weeks J, Fox RG, Zimdahl B, Ito T, Blevins A, Jung SH, Chute JP, Chourasia A, Covert MW, Reya T.
Nat Commun 7:12169 (2016).

2016.06.06: Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek MA, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T.
Nature 534:407-11 (2016).

2015.07.23: Tetraspanin 3 is required for the development and propagation of acute myelogenous leukemia.
Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T.
Cell Stem Cell 17:1-13 (2015).

2014.03.26: Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration.
Lento W, Ito T, Zhao C, Harris JR, Huang W, Jiang C, Owzar K, Piryani S, Racioppi L, Chao N, Reya T.
Genes Dev 28:995-1004 (2014).

2014.02.02: Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.
Zimdahl B#, Ito T#, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T.
Nat Genet 46:245-52 (2014).
Research highlighted in Nat Genet

2013.04.04: Stem cell maintenance and disease progression in chronic myeloid leukemia.
Ito T.
Int J Hematol 98:641-7 (2013).

2013.02.05: Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.
Kurokawa M, Ito T, Yang CS, Zhao C, Macincyte AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S.
Proc Natl Acad Sci U S A 110:2300-5 (2013).

2012.10.18: Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.
Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP.
Cell Rep 2:964-75 (2012).

2012.07.31: β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T.
Proc Natl Acad Sci U S A 109:12532-7 (2012).

2012.02.14: aSIRTing control over cancer stem cells.
Ito T, Zimdahl B, Reya T.
Cancer Cell 21:140-2 (2012).

2010.07.18: Regulation of myeloid leukaemia by the cell fate determinant Musashi.
Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T.
Nature 466:765-8 (2010).
Research highlighted in Nat Rev Cancer and F1000Prime

ITO Lab. – Cell Fate Dynamics and Therapeutics –